|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed the association between Crohn's disease and NOD2 (rs17313265, 0.28 in CD, 0.19 in controls, OR 1.5, p = 9×10-6) and IL23R (rs11209026, 0.026 in CD, 0.0.071 in controls, OR 0.4, p = 3.8×10-4).
|
25259511 |
2014 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC.
|
19276991 |
2009 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We also provide further evidence for association of rs11209026</span> with UC and a report of an additive effect between IL23R and CARD15 genotypes in CD.
|
17894849 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variants of CARD15 (3020insC and R702W) and IL23R (rs1004819, rs11209026, and rs1088967) were associated with CD.
|
18200510 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This data provides an explanation for the protective role of R381Q in CD and may lead to the development of improved therapeutics for autoimmune disorders like CD.
|
22022372 |
2011 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These observations suggest that IL23R makes a substantial contribution to CD susceptibility, larger than that estimated from the population frequency of the R381Q variant.
|
18470928 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females.
|
19294505 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rare Q allele of IL23R rs11209026 polymorphism was underrepresented in both paediatric and adult CD cases (P = 0.0018 and P = 0.04, respectively) and no difference was observed between the childhood and the adult cohort.
|
20380008 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rare allele of a non-synonymous interleukin 23 receptor (IL23R) single nucleotide polymorphism (SNP) rs11209026 (p.Arg381Gln) confers strong protection against Crohn disease (CD) and psoriasis.
|
18647855 |
2009 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs11209026 SNP, which is the most strongly associated with Crohn's disease, was not associated with GD or GO in our data set.
|
18073300 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The p.Arg381Gln IL23R variant confers a protective effect against both CD and UC, but does not determine disease phenotype.
|
17877509 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Specifically the G149R, V362I, and R381Q IL23Rα chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans.
|
26887945 |
2016 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently an association was shown between the single nucleotide polymorphism (SNP), rs11209026, within the interleukin-23 receptor (IL23R) locus and Crohn's disease (CD) as a consequence of a genome-wide association study of this disease in adults.
|
17618837 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent studies have shown that a nonsynonymous single-nucleotide polymorphism (SNP) (Arg381Gln; rs11209026) in the interleukin-23 receptor (IL-23R) gene on chromosome 1p31 is associated with Crohn's disease and psoriasis.
|
18383363 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15; rs2241880 A/G of ATG16L1, and rs11209026 (R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals.
|
20380008 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study provides additional support for the strong protection of the rs11209026 (p.Arg381Gln) variant against paediatric CD.
|
20192940 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis supports that two polymorphisms (Arg381Gln and rs7517847) within the IL-23R gene may be considered to be protective factors against developing CD.
|
20157760 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
One, an uncommon coding variant (rs11209026) in the gene encoding for the interleukin-23 receptor (IL23R), conferred strong protection against CD.
|
18047540 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2.
|
22293688 |
2012 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2.
|
22293688 |
2012 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2.
|
22293688 |
2012 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
|
17447842 |
2007 |